| 1966 | Recorded 'Blues Breakers with Eric Clapton' alongside John Mayall, a record so revered in the London blues scene that fans began scrawling 'Clapton is God' on walls across the city. |
| 1968 | Cream's 'Wheels of Fire' reached number one in the US, demonstrating how his fiery, improvisational guitar style could anchor a hard-rock power trio to commercial as well as critical heights. |
| 1970 | Formed Derek and the Dominos and recorded 'Layla and Other Assorted Love Songs', including the era-defining title track, one of rock's most recognizable guitar riffs. |
| 1992 | Performed an acoustic set for MTV Unplugged that produced six Grammy wins including Album of the Year, making 'Unplugged' one of the best-selling live records in history. |
| 1992 | Inducted into the Rock and Roll Hall of Fame with The Yardbirds, the first of three separate inductions that would make him the only artist so honored three times. |
| 2000 | Entered the Rock and Roll Hall of Fame as a solo artist, his third induction, joining prior entries with The Yardbirds and Cream. |
| 2016 | Released 'I Still Do', his first non-holiday studio album in a decade, reaffirming his standing as a living blues-rock institution entering his fourth decade as a solo artist. |
| 2021 | Released 'The Lady in the Balcony: Lockdown Sessions', an intimate acoustic set filmed at Cowdray House that offered fans a stripped-back performance during the pandemic era. |
| 2023 | Hosted the Crossroads Guitar Festival over two nights at Crypto.com Arena in Los Angeles, gathering 41 acts including Santana, John Mayer, Gary Clark Jr., Sheryl Crow, and ZZ Top. |
| 2024 | 'Meanwhile', his twenty-second solo studio album on Bushbranch/Surfdog Records, featured new collaborations with Van Morrison and Jeff Beck alongside six original tracks produced with longtime partner Simon Climie. |