| 2011 | Debuted on MTV's Guy Code in its early seasons, earning his first national television platform alongside Charlamagne tha God, and later expanded the exposure into the network's spinoff Guy Court and the short-lived dating series The Hook-Up. |
| 2014 | Co-launched The Brilliant Idiots podcast with Charlamagne tha God, translating the comedic chemistry they built on Guy Code into a weekly Loud Speakers Network show that grew past 300 episodes and 400,000 loyal YouTube subscribers. |
| 2017 | Self-released the stand-up special 4:4:1 on YouTube on September 13, capturing four New York City club sets in a single night, drawing over 1.4 million views, and setting up the follow-up album 5:5:1, which hit number one on Billboard's comedy chart. |
| 2017 | Co-founded the Flagrant podcast with Akaash Singh, launching a biweekly comedy and pop culture show that later added producer Alexx Media and comic Mark Gagnon to become one of comedy's biggest, top-charting podcasts on Apple and Spotify. |
| 2020 | Premiered the four-part Netflix special Schulz Saves America on December 17, tackling the pandemic, Black Lives Matter protests, conspiracy theories, and a divided electorate as his first solo stand-up special for the streaming platform, drawing wide media coverage. |
| 2022 | Released the special Infamous on July 17 after buying back the rights himself when a streamer moved to censor it, self-distributing it through TheAndrewSchulz.com, and posting the full hour on YouTube to more than 10 million views. |
| 2023 | Co-starred in the Netflix film You People alongside Jonah Hill and Eddie Murphy, playing a supporting role that marked one of his most visible mainstream acting credits and expanded his resume beyond stand-up and podcasting. |
| 2024 | Interviewed presidential candidate Donald Trump on Flagrant on October 9, a nearly 90-minute sit-down that drew 2.8 million YouTube views within 48 hours and prompted the Brooklyn Academy of Music to cancel his scheduled stand-up show. |
| 2024 | Headlined arenas throughout the Life Tour, selling out Madison Square Garden twice in a single May weekend and topping the bill at major stops including the Kia Forum, Crypto.com Arena, and Toronto's Scotiabank Arena, en route to a 60-city global run. |
| 2025 | Premiered his second Netflix special, Life, on March 4, filmed during a record-setting run at New York's Beacon Theatre and centered on becoming a father, including a candid breakdown of IVF, his most personal hour since Schulz Saves America. |
